Several Common Respiratory Viral Pathogens in Hematopoietic Stem Cell Transplantion Patients with Primary Immunodeficiency Disease.
10.19746/j.cnki.issn.1009-2137.2020.03.051
- Author:
Yu HUANG
1
,
2
,
3
,
4
;
Zhi CHEN
1
,
2
,
3
,
4
;
Yan MENG
3
,
5
,
6
,
7
;
Xian-Min GUAN
3
,
5
,
6
,
7
;
Jie YU
3
,
5
,
6
,
7
;
Xiao-Dong ZHAO
1
,
2
,
3
,
4
;
Ying DOU
3
,
5
,
6
,
8
Author Information
1. Pediatric Research Institute, Children's Hospital of Chongqing Medical University
2. Chongqing Key Laboratory of Child Infection and Immunity,Ministry of Education Key Laboratory of Child Development and Disorders
3. National Clinical Research Center for Child Health and Disorder
4. China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics.
5. Ministry of Education Key Laboratory of Child Development and Disorders
6. China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics,Department of Hematology and Oncology, Children's Hospital of Chongqing Medical University
7. Chongqing, 400014, China.
8. Chongqing, 400014, China,Email: douying523@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Humans;
Metapneumovirus;
Primary Immunodeficiency Diseases;
therapy;
Respiratory Syncytial Virus, Human;
Respiratory Tract Infections
- From:
Journal of Experimental Hematology
2020;28(3):1025-1031
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the prevalence of respiratory viral infections in patients with primary immunodeficiency disease (PID) during hematopoietic stem cell transplantation.
METHODS:108 specimens of nasopharyngeal aspirate were collected from 22 PID patients before and after hematopoietic stem cell transplantation from July 2016 to July 2018 in the Department of Hematology. The TR-PCR was used to detect for respiratory viruses including respiratory syncytial virus(RSV)，human metapneumoviros(hMPV)，coronavirus(CoV) and parainfluenza 1-3 (PIV1-3). And the clinical characteristics and co-infection were analyzed.
RESULTS:Among the total 108 specimens, viral pathogens were identified in 41 (37.96%) specimens. Among which the pathogens of highest detection rate was RSV (25.9%). Different types of PID showed different virus infection rates, among which the highest infection rate was severe combined immunodeficiency disease (SCID) patients, with the virus detection rate was 57.9%. The incidence of co-infection with two or more than two viruses was 19.5%.
CONCLUSION:Patients with PID who undergo hematopoietic stem cell transplantation are more susceptible to respiratory viruses. RSV is an important respiratory tract virus pathogen after hematopoietic stem cell transplantation.
