Hematopoietic Stem Cells Differentiate into the Megakaryocyte Lineage--Review.
10.19746/j.cnki.issn.1009-2137.2020.03.054
- Author:
Sen ZHANG
1
;
Fang DONG
1
;
Zi-Xian LIU
1
;
Hideo EMA
2
Author Information
1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical, Sciences & Peking Union Medical College, Tianjin 300020, China.
2. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical, Sciences & Peking Union Medical College, Tianjin 300020, China,E-mail: hema@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
Cell Lineage;
Hematopoiesis;
Hematopoietic Stem Cells;
Megakaryocytes;
Multipotent Stem Cells
- From:
Journal of Experimental Hematology
2020;28(3):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
Abstract Hematopoietic stem cells are able to self-renewal and differentiate to all blood lineages. With the development of new technologies, recent studies have proposed the revised versions of hematopoiesis. In the classical model of hematopoietic differentiation, HSCs were located at the apex of hematopoietic hierarchy. During differentiation process, HSCs progressively lose self-renewal potential to be commited to progenitors with restricted differentiation potential. For instance, HSCs first give rise to multipotent progenitor cells, then produce bipotent and unipotent progenitors, and finally differentiate to mature blood cells. For the differentiation of megakaryocytes, common myeloid progenitors derived from HSCs give rise to megakaryocyte-erythrocyte progenitors and then develop to megakaryocytes. However, recent results show that megakaryocytes can be directly generated from HSCs without multipotent or bipotent phases. Alternatively, platelet-biased HSCs produce megakaryocyte progenitors. In this article, recent advances in the hematopoiesis and megakaryocyte differentiation pathway are reviewed.
