Application of Single Cell Sequencing in Diagnosis and Treatment of Malignant Hematological Diseases--Review.
10.19746/j.cnki.issn.1009-2137.2020.03.057
- Author:
Ming-Jing WANG
1
;
Wei-Yi LIU
2
;
Xiao-Mei HU
3
Author Information
1. Department of Hematology, Xiyuan Hospital, China Academy of Traditional Chinese Medical Sciences, Beijing 100091, China,Graduate School of China Academy of Traditional Chinese Medical Sciences, Beijing 100700, China.
2. Department of Hematology, Xiyuan Hospital, China Academy of Traditional Chinese Medical Sciences, Beijing 100091, China.
3. Department of Hematology, Xiyuan Hospital, China Academy of Traditional Chinese Medical Sciences, Beijing 100091, China,E-mail: huxiaomei_2@163.com.
- Publication Type:Journal Article
- MeSH:
Hematologic Diseases;
Humans;
Leukemia, Myeloid, Acute;
Myelodysplastic Syndromes;
Myeloproliferative Disorders;
Sequence Analysis
- From:
Journal of Experimental Hematology
2020;28(3):1059-1063
- CountryChina
- Language:Chinese
-
Abstract:
Abstract Single cell sequencing technology is different from traditional sequencing method, which is based on population cell average level. It has been widely used in many fields and made great progress in the application of malignant hematological diseases. In this review, the principle, methodology and application of single cell sequencing technology in malignant hematological diseases are summarized briefly, including the study of the pathogenesis in myelodysplastic syndrome, the mechanism of transformation into leukemia, accurate diagnosis and classification, differential diagnosis, evaluation of targeted drug therapeutic efficacy and exploration of biomarkers; specific diagnostic indicators for myeloproliferative diseases, progression of disease monitoring and epidemiological studies; moreover, the pathogenesis and drug resistance of acute myeloid leukemia (AML), which can provide reference for the diagnosis and research of malignant hematological diseases.
