Expression Level of MiR-146a in Acute Myeloid Leukemia Patients and Its Clinical Significance.
10.19746/j.cnki.issn.1009-2137.2020.04.015
- Author:
Yi-Li WANG
1
;
Xiu-Zhi DENG
1
;
Chun-Jing TANG
1
;
Xiao-Yi WANG
1
;
Jie YU
2
Author Information
1. Department of Hematology, Weihai Municipal Hospital, Weihai 264200, Shandong Province, China.
2. Department of Hematology, Weihai Municipal Hospital, Weihai 264200, Shandong Province, China,E-mail: jiulin25558011@163.com.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Humans;
Leukemia, Myeloid, Acute;
MicroRNAs;
Prognosis
- From:
Journal of Experimental Hematology
2020;28(4):1171-1176
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of miR-146a in patients with AML, and to evaluate the relationship between miR-146a expression level and clinical characteristics, treatment response, EFS and OS.
METHODS:154 patients with newly diagnosed AML were enrolled in AML group, 50 controls (patients with thrombocytopenic purpura or voluntary donor of bone marrow) were enrolled in control group. The miR-146a expression levels in bone marrow mononuclear cells was detected by RT-PCR between 2 group. AML patients were treated with chemotherapeutic drugs, and their clinical response and survivals were assessed.
RESULTS:The expression level of MiR-146a in AML group was significantly lower than that in control group. The ROC showed that miR-146a could distinguish the patients in AML and control group better (area under curve 0.819 (95%CI: 0.761-0.877). Meanwhile, the proportion of good and moderate good prognosis (P＜0.001), proportion of WBC count ≤15.2×10/L (P＜0.05), CR rate (P＜0.05), EFS (P＜0.01) and OS (P＜0.01) in patients with high miR-146a expression were higher than those in patients with low miR-146a expression. Cox's model showed that miR-146a expression level positively realated with incressed EFS and OS.
CONCLUSION:MiR-146a is downregulated in AML patients, which might be served as a biomarker for predicting risk and prognosis of AML patients.
