Level of Coagulation Function Indexes and Its Clinical Significance in Patients with Lymphoplasmacytic Lymphoma.
10.19746/j.cnki.issn.1009-2137.2020.04.020
- Author:
Xiao-Ping LIANG
1
;
Hai-Dong WANG
2
;
Ming-Ming SHAO
1
;
Ni LI
3
;
Wen-Xia HAN
1
Author Information
1. College of Medical Technology, Xi'an Medical University, Xi'an 710021, Shaanxi Province, China.
2. Department of Clinical Laboratorial Examination, The Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, Shaanxi Province, China.
3. College of Medical Technology, Xi'an Medical University, Xi'an 710021, Shaanxi Province, China,E-mail: 274835616@qq.com.
- Publication Type:Journal Article
- MeSH:
Adult;
Blood Coagulation;
Blood Coagulation Tests;
Humans;
Lymphoma;
Partial Thromboplastin Time;
Prothrombin Time;
Thrombosis
- From:
Journal of Experimental Hematology
2020;28(4):1205-1209
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the level of coagulation function indexes in patients with lymphoplasmacytic lymphoma (LPL) and its clinical significance.
METHODS:The clinical data of 32 patients with initial LPL (LPL group) and physical examination data of 25 healthy persons (control group) who underwent physical examination in our hospital during the same period were collected. The differences of platelet (Plt), D-Dimer (D-D), fibrinogen (Fib), thrombin time (TT), prothrombin time (PT) and activated partial thrombin time (APTT) between the two groups were compared.
RESULTS:The Plt count in LPL group [ (137.06±40.14)×10/L] was significantly lower than that in control group [ (215.07±33.25)×10/L], D-D [ (1.01±0.16) mg/L, PT [ (13.01±1.37) s] and APTT [ (40.96±7.24) s] in LPL group were significantly higher than those in control group [ (0.37±0.09) mg/L, (11.96±0.87) s, (25.07±5.13) s] (P＜0.01); there was no significant difference in TT and Fib levels between the two groups (P＞0.05). There was no significant difference in Plt, D-D, Fib, AP, TT and APTT among LPL patients secreting different types of immunoglobulin (Ig) (P＞0.05). After treatment, the coagulation function of LPL patients returned to normal, and no death cases occurred due to hemorrhage or thrombosis.
CONCLUSION:LPL patients have hypercoagulable state blood and abnormal coagulation function, but which not closely relates to with the type of Ig secreted by patients.
