Clinical Characteristics and Bone Marrow Histopathology Features in Essential Thrombocythaemia Patients with Different Gene Mutation in China.
10.19746/j.cnki.issn.1009-2137.2020.04.042
- Author:
Xiu-Peng YE
1
;
Rong WANG
2
;
Quan-Gui WANG
3
;
Yan WANG
2
;
Jian-Fu ZHANG
2
;
Chun QIAO
2
;
Hong-Juan LIU
1
;
Ke-Danmu Aierken AI
1
;
Xing-Xing CHAI
2
;
Xing-Yu LU
2
;
Xiao-Qing LIU
2
;
Lang CHEN
2
;
Zheng-Yuan LIU
2
;
Ye-Qiong LI
1
;
Chun-Yu ZHANG
1
;
Fang LI
1
;
Guang-Sheng HE
4
;
Shen BAO
5
Author Information
1. Department of Hematology-Oncology, The First Affiliated Hospital of Northwest University for Nationalities, Ningxia People's Hospital, Yinchuan 750002, Ningxia Hui Autonomous Region, China.
2. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China.
3. Guyuan people's Hospital, Guyuan 756000, Ningxia Hui Autonomous Region, China.
4. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, Jiangsu Province, China,E-mail: heguangsheng1972@sina.com.
5. Department of Hematology-Oncology, The First Affiliated Hospital of Northwest University for Nationalities, Ningxia People's Hospital, Yinchuan 750002, Ningxia Hui Autonomous Region, China,E -mail: yxp4200338@163.com.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Calreticulin;
genetics;
China;
Humans;
Janus Kinase 2;
genetics;
Male;
Mutation;
Receptors, Thrombopoietin;
genetics;
Thrombocythemia, Essential
- From:
Journal of Experimental Hematology
2020;28(4):1326-1331
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical characteristics, laboratorial and bone marrow pathological features of primary thrombocytopenia (ET) patients with different mutations of CALR, JAK2 and MPL genes.
METHODS:The chinical data of 120 cases of ET in Jiangsu provincial people's hospital/ The First Affiliated Hospital of Nanjing Medical University from January 2015 to December 2017 were collected and analyzed, including 76 cases with JAK2 gene mutation, 40 cases with CALR gene mutation, 2 cases with MPL gene mutations, 2 cases without gene mutation.
RESULTS:Among the ET patients, compared with the JAK2 gene mutation, CALR gene mutation showed statistically significant deareament of white blood cells and hemoglobin (P=0.001, P=0.01) and the male platelets in CALR group showed significant increament (P=0.04). Fourthermore, the average number of megakaryocytes and its cluster numbers in each hight power field of vision showed statistically significant decreament in CALR group as compared with JAK2 group (P=0.001, P=0.001), and thrombotic events in CALR group were signicantly lower than those in JAK2 group (7.5% vs 18.4%) (P=0.03).
CONCLUSION:Mutations of CALR, JAK2 have different clinical characteristics and blood pathological changes of Chinese ET patients, and their clinical significance is worth to explore.
