Value of MiR-155 in Prognostic Evaluation of Elderly Patients with Primary Immune Thrombocytopenia.
10.19746/j.cnki.issn.1009-2137.2020.04.044
- Author:
Ying HE
1
;
Xue-Hua WEI
2
;
Xiu-Mei ZAO
2
Author Information
1. Department of Hematology, The First People's Hospital of Yinchuan, Yinchuan 750001, Ningxia Hui Autonomous Region, China,E-mail：heying6590@163.com.
2. Department of Hematology, The First People's Hospital of Yinchuan, Yinchuan 750001, Ningxia Hui Autonomous Region, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Biomarkers, Tumor;
Humans;
Kaplan-Meier Estimate;
Leukocytes, Mononuclear;
MicroRNAs;
Neoplasm Recurrence, Local;
Prognosis;
Purpura, Thrombocytopenic, Idiopathic
- From:
Journal of Experimental Hematology
2020;28(4):1338-1343
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the value of has-microRNA-155 (miR-155) in peripheral blood mononuclear cells (PBMNC) in prognostic evaluation of elderly patients with primary immune thrombocytopenia (PITP).
METHODS:One hundred and thirty elderly PITP patients and 60 healthy volunteers in our hospital were selected. The relative expression level of miR-155 in PBMNC was detected by RT-PCR. Unconditional logistic multivariate regression analysis was used to analyze the relationship between miR-155 expression and prognosis of PITP patients, and Kaplan-Meier was further used to analyze the relationship between miR-155 and PITP recurrence.
RESULTS:The relative expression level of miR-155 in PBMNC of elderly PITP patients was significantly higher than that in healthy volunteers, and increased significantly with the severity of the disease (P＜0.05). The overall effective rate of elderly PITP patients with miR-155 low-expression was significantly higher than that in the patients with miR-155 high-expression (96.92% vs 72.31%) by after treatment with glucocorticoid. Multivariate analysis showed that miR-155 was an independent risk factor for PITP patients. Elderly patients with high expression of miR-155 showed a higher risk of recurrence.
CONCLUSION:miR-155 in PBMNC has a high accuracy for PITP diagnosis, and the elderly patients with high level of miR-155 show a poor prognosis and a higher risk of recurrence.
