Influencing Factors and Prevation of Infection in Leukemia Patients after Allogeneic Peripheral Blood Stem Cell Transplantation.
10.19746/j.cnki.issn.1009-2137.2020.04.045
- Author:
Ya-Qiong SHEN
1
;
Yue-Yue FU
1
;
Li-Min LI
2
;
Yan WANG
1
;
Ling-Ling MENG
1
;
Qiu-Yan ZHAI
1
Author Information
1. Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
2. Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China,E-mail: 279004402@qq.com.
- Publication Type:Journal Article
- MeSH:
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Humans;
Infections;
Leukemia;
Peripheral Blood Stem Cell Transplantation
- From:
Journal of Experimental Hematology
2020;28(4):1344-1348
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the influencing factors and countermeasures of infection in leukemia patients after allogeneic peripheral blood hematopoietic stem cell transplantation.
METHODS:A total of 126 patients with leukemia admitted in our hospital from August 2016 to March 2018 were selected. The number of infected patients after transplantation was recorded, and the causes of infection were analyzed.
RESULTS:Among the 126 patients, 43 were positive for infection, and the infection rate was 34.13%. A total of 89 pathogens were detected, of which bacteria accounted for 64.05%; virus accounted for 22.47%, and fungi accounted for 13.48%. The patient's age, donor type, pre-transplant infection, prophylactic use of antibiotics and aGVHD all were factors influencing the patient's infection (P＜0.05). The follow-up results showed that the incidence of infection in the intervention group significantly decreased after intervention with prevention program (P＜0.05). After reasonable nursing intervention, the incidence of infection in the intervention group after follow-up for 12 months was lower than that in the control group (P＜0.05).
CONCLUSION:Pre-transplant infection and prophylactic use of antibiotics are factors influencing the infection after allogeneic hematopoietic stem cell transplantation. The incidence of infection can be reduced by reasonable infection prevention.
