Divergent effects of lycopene on pancreatic alpha and beta cells.
- Author:
Wei-Huang LIU
1
;
Qiao-Na WANG
1
;
Ying ZHOU
1
;
Yan-Jun WANG
1
;
Zan TONG
2
Author Information
1. School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
2. School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China. ztong@whu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Adenosine Triphosphate;
metabolism;
Apoptosis;
Carotenoids;
pharmacology;
Cell Cycle;
Cells, Cultured;
Cytokines;
metabolism;
Glucagon-Secreting Cells;
drug effects;
Humans;
Insulin-Secreting Cells;
drug effects;
Lycopene;
pharmacology;
Reactive Oxygen Species;
metabolism
- From:
Acta Physiologica Sinica
2020;72(2):133-138
- CountryChina
- Language:English
-
Abstract:
Lycopene is an antioxidant which has potential anti-diabetic activity, but the cellular mechanisms have not been clarified. In this study, different concentrations of lycopene were used to treat pancreatic alpha and beta cell lines, and the changes of cell growth, cell apoptosis, cell cycle, reactive oxygen species (ROS), ATP levels and expression of related cytokines were determined. The results exhibited that lycopene did not affect cell growth, cell apoptosis, cell cycle, ROS and ATP levels of alpha cells, while it promoted the growth of beta cells, increased the ratio of S phase, reduced the ROS levels and increased the ATP levels of beta cells. At the same time, lycopene treatment elevated the mRNA expression levels of tnfα, tgfβ and hif1α in beta cells. These findings suggest that lycopene plays cell-specific role and activates pancreatic beta cells, supporting its application in diabetes therapy.
