Source, metabolism and function of dopamine in digestive tract.
- Author:
Chen-Zhe LIU
1
;
Jin-Xia ZHU
2
Author Information
1. Department of Exercise Physiology, Beijing Sport University, Beijing 100084, China.
2. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. zhu_jx@ccmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Catechol O-Methyltransferase;
Catechol O-Methyltransferase Inhibitors;
Dopamine;
Gastrointestinal Tract;
Monoamine Oxidase;
Monoamine Oxidase Inhibitors
- From:
Acta Physiologica Sinica
2020;72(3):336-346
- CountryChina
- Language:Chinese
-
Abstract:
Dopamine (DA), as a catecholamine neurotransmitter widely distributed in the central nervous system and the peripheral tissues, has attracted a lot of attention. Especially in recent years, DA has been found to regulate the function of the immune system, and the involvement of DA in the intestinal mucosal inflammation-related diseases has become a hot research topic. The digestive tract is an important source of peripheral DA, and DA is not only produced in the enteric nervous system and gastrointestinal epithelium, but also produced by intestinal microorganisms. In addition to the synthetases of DA, the DA contents in body tissues are also affected by the two kinds of metabolic enzymes, monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). This article reviewed the sources, metabolism, and functions of DA in digestive tract, especially focusing on the distribution and function of MAO and COMT, the enzymes degrading DA.
