Effects and pathophysiological significance of intestinal flora on the enteric neuro-endocrine-immune system.
- Author:
Han-Nan XU
1
;
Zheng-Zhen CAI
1
;
Yun WANG
1
;
Duo-Er WU
1
;
Wei-Fang RONG
1
;
Guo-Hua ZHANG
2
Author Information
1. Department of Anatomy and Physiology, Basic Medical School, Shanghai Jiao Tong University, Shanghai 200025, China.
2. Department of Anatomy and Physiology, Basic Medical School, Shanghai Jiao Tong University, Shanghai 200025, China. ghzhang2009@shsmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Enteric Nervous System;
Gastrointestinal Diseases;
Gastrointestinal Microbiome;
Humans;
Immune System
- From:
Acta Physiologica Sinica
2020;72(3):347-360
- CountryChina
- Language:Chinese
-
Abstract:
Interactions among the nervous, the endocrine and the immune systems enable the gut to respond to the dietary products, pathogens and microbiota, which maintains the homeostasis of the body. However, dysbiosis may induce or aggravate the gastrointestinal (GI) and extra-GI diseases through changing the activities of enteric nervous system (ENS), enteroendocrine cells and enteric immune cells. Here we review recent advances in the understandings on how intestinal flora may impact the enteric neuro-endocrine-immune system in the gut, thereby contributing to the regulation of pathophysiological processes.
