Role of calcitonin gene-related peptide in regulation of synaptic plasticity and process of the emotional memory.
- Author:
Xin WU
1
;
Dong-Hui WANG
1
;
Jian-Feng GAO
2
Author Information
1. School of Basic Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
2. School of Basic Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China. jc.gjfeng@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Calcitonin;
Calcitonin Gene-Related Peptide;
Central Nervous System;
Humans;
Memory;
Neuronal Plasticity
- From:
Acta Physiologica Sinica
2020;72(3):399-406
- CountryChina
- Language:Chinese
-
Abstract:
Calcitonin gene-related peptide (CGRP) is a neuropeptide coded by the calcitonin gene and divided into α and β subtypes. CGRP is widely distributed throughout the human body and highly expressed in the peripheral and central nervous system. Studies have shown that CGRP plays a role in a variety of physiological and pathophysiological activities, such as the formation and transmission of nociceptive signal, as well as the regulation of cardiovascular function. Recently, more and more researches have shown that CGRP is involved in the regulation of synaptic plasticity, cognitive function and learning memory in the central nervous system. This paper reviews the role of CGRP in regulation of synaptic plasticity and process of emotional memory, hoping to provide a new molecular target and theoretical basis for clinical treatment of neurological diseases.
