Advances in molecular mechanisms of meiotic arrest and luteinizing hormone-induced meiotic resumption in oocytes.
- Author:
Xiao-Qiong HAO
1
;
Shao-Kai XU
2
;
Rui-Li SHI
1
Author Information
1. Department of Physiology, Baotou Medical College, Baotou 014040, China.
2. First Affiliated Hospital, Baotou Medical College, Baotou 014040, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cumulus Cells;
Female;
Luteinizing Hormone;
Meiosis;
Natriuretic Peptide, C-Type;
genetics;
Oocytes
- From:
Acta Physiologica Sinica
2020;72(4):513-522
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian oocytes within Graafian follicles are arrested at prophase I of meiosis. C-type natriuretic peptide (NPPC), secreted by mural granulosa cells (MGCs), maintains oocyte meiotic arrest via binding to its cognate receptor natriuretic peptide receptor 2 (NPR2) and producing cyclic guanosine monophosphate (cGMP). NPR2 is most concentrated in the cumulus cells. In addition, cAMP, gap junction, inosine monophosphate dehydrogenase (IMPDH) and other important regulatory factors are also involved in meiotic arrest. Luteinizing hormone (LH) then rapidly decreases cGMP and induces oocyte meiotic resumption. In this paper, advances in the molecular mechanisms of meiotic arrest and LH-induced meiotic resumption were reviewed. This paper may provide new ideas for the prevention, diagnosis and treatment of related reproductive diseases.
