Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids.
10.1007/s13238-020-00718-6
- Author:
Bing ZHAO
1
;
Chao NI
2
;
Ran GAO
3
;
Yuyan WANG
4
;
Li YANG
2
;
Jinsong WEI
2
;
Ting LV
5
;
Jianqing LIANG
2
;
Qisheng ZHANG
6
;
Wei XU
4
;
Youhua XIE
4
;
Xiaoyue WANG
3
;
Zhenghong YUAN
4
;
Junbo LIANG
7
;
Rong ZHANG
8
;
Xinhua LIN
9
Author Information
1. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. bingzhao@fudan.edu.cn.
2. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
3. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China.
4. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
5. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, 200040, China.
6. Sino Organoid Lifesciences Ltd., Shanghai, 201900, China.
7. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100005, China. liangjunbo@ibms.pumc.edu.cn.
8. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China. rong_zhang@fudan.edu.cn.
9. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. xlin@fudan.edu.cn.
- Publication Type:Letter
- MeSH:
Betacoronavirus;
isolation & purification;
pathogenicity;
Bile Acids and Salts;
metabolism;
Bile Ducts, Intrahepatic;
pathology;
virology;
Cell Culture Techniques;
Coronavirus Infections;
complications;
pathology;
Cytokine Release Syndrome;
etiology;
physiopathology;
Cytopathogenic Effect, Viral;
Epithelial Cells;
enzymology;
pathology;
virology;
Humans;
Hyperbilirubinemia;
etiology;
Liver;
pathology;
Organoids;
pathology;
virology;
Pandemics;
Peptidyl-Dipeptidase A;
analysis;
Pneumonia, Viral;
complications;
pathology;
Receptors, Virus;
analysis;
Serine Endopeptidases;
analysis;
Viral Load
- From:
Protein & Cell
2020;11(10):771-775
- CountryChina
- Language:English
