Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice.

Jinliang Wang; Lei Shuai; Chong Wang; Renqiang Liu; Xijun HE; Xianfeng Zhang; Ziruo Sun; Dan Shan; Jinying GE; Xijun Wang; Ronghong Hua; Gongxun Zhong; Zhiyuan Wen; Zhigao BU

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Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice.

Author: Jinliang WANG ¹ ; Lei SHUAI ¹ ; Chong WANG ¹ ; Renqiang LIU ¹ ; Xijun HE ² ; Xianfeng ZHANG ² ; Ziruo SUN ¹ ; Dan SHAN ¹ ; Jinying GE ¹ ; Xijun WANG ¹ ; Ronghong HUA ¹ ; Gongxun ZHONG ³ ; Zhiyuan WEN ⁴ ; Zhigao BU ⁵
Author Information

1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
2. National High Containment Laboratory for Animal Diseases Control and Prevention, Harbin, 150069, China.
3. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. zhonggongxun@caas.cn.
4. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. wenzhiyuan@caas.cn.
5. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China. buzhigao@caas.cn.
Publication Type:Letter
MeSH: Adaptation, Physiological; Adenosine Monophosphate; administration & dosage; analogs & derivatives; pharmacology; therapeutic use; Administration, Intranasal; Alanine; administration & dosage; analogs & derivatives; pharmacology; therapeutic use; Animals; Betacoronavirus; genetics; physiology; Chlorocebus aethiops; Coronavirus Infections; drug therapy; virology; Disease Models, Animal; Female; Host Specificity; genetics; Lung; pathology; virology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mutation, Missense; Nasal Mucosa; virology; Pandemics; Pneumonia, Viral; drug therapy; virology; RNA, Viral; administration & dosage; genetics; Turbinates; virology; Vero Cells; Viral Load; Virus Replication
From: Protein & Cell 2020;11(10):776-782
CountryChina
Language:English