Research progress in transdermal delivery for small interfering RNA.
- Author:
Yu CHEN
1
;
Nuo XU
1
;
Zhenlin HU
2
Author Information
- Publication Type:Journal Article
- Keywords: RNA interference; delivery vector; lipidosome; nanoparticles; polymers; skin diseases; small interfering RNA
- MeSH: Administration, Cutaneous; Genetic Vectors; administration & dosage; Humans; RNA, Small Interfering; administration & dosage; Skin Diseases; therapy
- From: Chinese Journal of Biotechnology 2020;36(4):622-631
- CountryChina
- Language:Chinese
- Abstract: Small interfering RNA (siRNA) has been used to treat various skin diseases. However, siRNA is limited in application due to its electronegativity, strong polarity, easy degradation by nuclease and difficulty in breaking through the skin barrier. Therefore, safe and efficient siRNA delivery vector is the premise of effective treatment of skin diseases by siRNA. In recent years, with the deepening of research on siRNA, great progress has been made in the development of delivery systems based on lipids, polymers, peptides and nanoparticles, some new transdermal delivery vectors of siRNA have emerged, such as liposomes, dendrimers, cell penetrating peptides, and spherical nucleic acid nanoparticles. This review will focus on the recent advance in siRNA transdermal delivery vectors.
