Predictors for the Bronchiolitis Obliterans Syndrome in Lung Transplant Patient.
10.3779/j.issn.1009-3419.2020.101.03
- Author:
Sijia YANG
1
;
Abudumailamu ABUDUWUFUER
1
;
Wang LV
1
;
Feichao BAO
1
;
Jian HU
1
Author Information
1. The First Affiliated Hospital, Collage of Medicine, Zhejiang University, Hangzhou 310003, China.
- Publication Type:Journal Article
- Keywords:
Bronchiolitis obliterans syndrome;
Lung transplantation;
Predictor
- From:
Chinese Journal of Lung Cancer
2020;23(6):496-502
- CountryChina
- Language:Chinese
-
Abstract:
Lung transplantation is the ultimate treatment of end-stage lung disease. After transplantation, the 1-year survival rate is 80%, while the 5-year survival rates remaines at around 50% mainly due to bronchiolitis obliterans syndrome (BOS). BOS is regarded as a fibrosing process in the small airways leading to irreversible airway obstruction. A lot of factors are involved in the development of BOS, such as Ischemia/reperfusion injury, infections, oxidative stress, and acute rejection, etc. Studies have shown that early diagnosis of BOS may improve outcome. It is valuable for the long-term survival of lung transplantation to find out several predictors for the BOS. This article reviews the current state of knowledge on predictors for BOS.
