Research Progress on Exosome in Malignant Tumors.

Author: Yujun ZHENG ¹ ; Wei JIANG ¹ ; Dongyan CHEN ¹ ; Lei WANG ¹ ; Yanjun LI ¹ ; Lulu DAI ¹ ; Lei HUANG ¹ ; Mingji WANG ¹
Author Information

1. Department of Oncology, The Friendship Hospital of Dalian, Dalian 116001, China.
Publication Type:Journal Article
Keywords: Exosomes; Malignant tumor; Tumorigenesis
From: Chinese Journal of Lung Cancer 2020;23(8):689-694
CountryChina
Language:Chinese
Abstract: "Liquid biopsy" have been intensively studied in recent decades. The exosomes carry their maternal partial functional proteins and genes. As a form of intercellular vesicular transport, exosome-mediated intercellular communication participates in a variety of physiological and pathological processes. The information transmission mediated by exosomes is associated with pathophysiological status and plays an important role in the pathogenesis of cancer. Their detection may be beneficial for the diagnosis and treatment of tumor. This article reviews advances in knowledge on the exosome properties, the effect of exosomes on malignant tumorigenesis, and their clinical application. The data will provide a reference for clinical practitioners.