Advances in molecular biology research on human parvovirus B19.

Yanming Dong; Jingjing LI; Peng XU; Yi LI; Lixin MA; Yuan Wang

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Advances in molecular biology research on human parvovirus B19.

Author: Yanming DONG ¹ ; Jingjing LI ² ; Peng XU ³ ; Yi LI ³ ; Lixin MA ¹ ; Yuan WANG ⁴
Author Information

1. State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan 430062, Hubei, China.
2. Hubei Key Laboratory of Edible Wild Plants Conservation and Utilization, Hubei Normal University, Huangshi 435002, Hubei, China.
3. School of Life Sciences and Technology, Wuhan University of Bioengineering, Wuhan 430415, Hubei, China.
4. College of Medical, Hubei University of Arts and Science, Xiangyang 441053, Hubei, China.
Publication Type:Journal Article
Keywords: genomic features; genotypes; parvovirus B19; transcriptional and post-transcriptional regulation; viral diagnosis and antiviral agents; viral protein features and function
MeSH: Antiviral Agents; DNA, Viral; genetics; Erythema Infectiosum; diagnosis; virology; Genotype; Humans; Parvovirus B19, Human; genetics; Virology; trends; Virus Replication
From: Chinese Journal of Biotechnology 2020;36(5):879-890
CountryChina
Language:Chinese
Abstract: Human parvovirus B19 (B19 virus) is one of the two parvoviruses that cause human diseases. As an important pathogen to humans, it causes infectious erythema in children, acute aplastic anemia, fetal edema and death. In this review, we focus on the recent advances in the molecular virology of B19V, such as viral genotypes, viral receptor, genomic features and viral replication, viral transcription and post-transcription regulation, viral nonstructural and structural protein features and functions, viral diagnosis and antiviral agents, to provide reference for further study of B19 pathogenesis mechanisms, treatment and diagnostic strategies.