- Author:
Yanming DONG
1
;
Jingjing LI
2
;
Peng XU
3
;
Yi LI
3
;
Lixin MA
1
;
Yuan WANG
4
Author Information
- Publication Type:Journal Article
- Keywords: genomic features; genotypes; parvovirus B19; transcriptional and post-transcriptional regulation; viral diagnosis and antiviral agents; viral protein features and function
- MeSH: Antiviral Agents; DNA, Viral; genetics; Erythema Infectiosum; diagnosis; virology; Genotype; Humans; Parvovirus B19, Human; genetics; Virology; trends; Virus Replication
- From: Chinese Journal of Biotechnology 2020;36(5):879-890
- CountryChina
- Language:Chinese
- Abstract: Human parvovirus B19 (B19 virus) is one of the two parvoviruses that cause human diseases. As an important pathogen to humans, it causes infectious erythema in children, acute aplastic anemia, fetal edema and death. In this review, we focus on the recent advances in the molecular virology of B19V, such as viral genotypes, viral receptor, genomic features and viral replication, viral transcription and post-transcription regulation, viral nonstructural and structural protein features and functions, viral diagnosis and antiviral agents, to provide reference for further study of B19 pathogenesis mechanisms, treatment and diagnostic strategies.