Progress in metabolic engineering of biosynthesis of 3-hydroxypropionic acid.

Author: Yuanlong ZHAN ¹ ; Ruiying ZHAO ¹ ; Hongliang CUI ¹ ; Huatai LI ¹ ; Zhifeng SONG ¹ ; Changli LIU ¹
Author Information

1. College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
Publication Type:Journal Article
Keywords: 3-hydroxypropionic acid; glycerol pathway; malonyl-CoA pathway; metabolic engineering; β-alanine pathway
MeSH: Glycerol; metabolism; Industrial Microbiology; trends; Lactic Acid; analogs & derivatives; biosynthesis; Metabolic Engineering; Metabolic Networks and Pathways; genetics
From: Chinese Journal of Biotechnology 2020;36(6):1101-1112
CountryChina
Language:Chinese
Abstract: As an important platform compound, 3-hydroxypropionic acid (3-HP) can be used as a substrate to synthesize a variety of biological products with commercial potential. The titer of 3-HP by wild-type bacteria is low, which severely limits the large-scale application and production of 3-HP. By modifying the genes related to the metabolic pathway, engineered bacteria using cheap substrates as carbon sources are constructed, the aim of reducing production cost and increasing output is realized. In this paper, the recent progress in the synthesis of 3-HP by metabolic engineering at home and abroad is reviewed. The advantages and disadvantages of glycerol pathway, malonyl-CoA pathway and beta-alanine pathway for synthesis of 3-HP are also summarized and analyzed, and the future development of 3-HP is prospected.