Current progress in antimicrobial peptides against bacterial biofilms.

Author: Wenbo WANG ¹ ; Guannan WANG ¹ ; Shasha CAI ¹
Author Information

1. The Key Laboratory for Medical Tissue Engineering, College of Medical Engineering, Jining Medical University, Jining 272000, Shandong, China.
Publication Type:Journal Article
Keywords: anti-biofilm mechanisms; antimicrobial peptides; bacterial biofilm
MeSH: Anti-Bacterial Agents; pharmacology; Antimicrobial Cationic Peptides; pharmacology; Bacteria; drug effects; Biofilms; drug effects; Drug Resistance, Bacterial; drug effects; Microbial Sensitivity Tests; Research; trends
From: Chinese Journal of Biotechnology 2020;36(7):1277-1282
CountryChina
Language:Chinese
Abstract: Microbial biofilm, a consortium of microbial cells protected by a self-produced polymer matrix, is considered as one main cause of current bacterial drug resistance. As a new type of antimicrobial agents, antimicrobial peptides provide a new strategy for the treatment of antibiotic resistant bacteria biofilm infections. Antimicrobial peptides have shown unique advantages in preventing microbial colonization of surfaces, killing bacteria in biofilms or disrupting the mature biofilm structure. This review systemically analyzes published data in the recent 30 years to summarize the possible anti-biofilm mechanisms of antimicrobial peptides. We hope that this review can provide reference for the treatment of infectious diseases by pathogenic microbial biofilm.