Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease.
10.1007/s12264-020-00498-3
- Author:
Lin ZHU
1
;
Zan WANG
1
;
Zhanhong DU
2
;
Xinyang QI
1
;
Hao SHU
1
;
Duan LIU
1
;
Fan SU
1
;
Qing YE
1
;
Xuemei LIU
2
;
Zheng ZHOU
2
;
Yongqiang TANG
2
;
Ru SONG
2
;
Xiaobin WANG
3
;
Li LIN
4
;
Shijiang LI
5
;
Ying HAN
6
;
Liping WANG
7
;
Zhijun ZHANG
8
Author Information
1. Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
2. Shenzhen Key Laboratory of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, Chinese Academy of Science (CAS) Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China.
3. Laboratory Animal Center, Southeast University, Nanjing, 210009, China.
4. Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing, 100053, China.
5. Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
6. Department of Neurology, Xuan Wu Hospital of Capital Medical University, Beijing, 100053, China. hanying@xwh.ccmu.edu.cn.
7. Shenzhen Key Laboratory of Neuropsychiatric Modulation, Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, Chinese Academy of Science (CAS) Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, 518055, China. lp.wang@siat.ac.cn.
8. Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, China. janemengzhang@vip.163.com.
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
Amnestic mild cognitive impairment;
Postrhinal cortex;
Uncinate fasciculus;
Ventral lateral orbitofrontal cortex;
Visuospatial memory
- From:
Neuroscience Bulletin
2020;36(8):831-844
- CountryChina
- Language:English
-
Abstract:
The parahippocampal gyrus-orbitofrontal cortex (PHG-OFC) circuit in humans is homologous to the postrhinal cortex (POR)-ventral lateral orbitofrontal cortex (vlOFC) circuit in rodents. Both are associated with visuospatial malfunctions in Alzheimer's disease (AD). However, the underlying mechanisms remain to be elucidated. In this study, we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice, and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging (MRI) in patients on the AD spectrum. We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice. Moreover, MRI measurements of the PHG-OFC circuit had an accuracy of 77.33% for the classification of amnestic mild cognitive impairment converters versus non-converters. Thus, the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD, thereby providing a potential predictor for AD progression and a promising interventional approach for AD.
