Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure history in Zhejiang Province, China.
- Author:
Jiang-Shan LIAN
1
;
Huan CAI
1
;
Shao-Rui HAO
1
;
Xi JIN
2
;
Xiao-Li ZHANG
1
;
Lin ZHENG
1
;
Hong-Yu JIA
1
;
Jian-Hua HU
1
;
Shan-Yan ZHANG
1
;
Guo-Dong YU
1
;
Jue-Qing GU
1
;
Chan-Yuan YE
1
;
Ci-Liang JIN
1
;
Ying-Feng LU
1
;
Ji-Fang SHENG
1
;
Yi-da YANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Coronavirus disease 2019 (COVID-19); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Zhejiang Province; Wuhan
- MeSH: Adolescent; Adult; Aged; Aspartate Aminotransferases; blood; Betacoronavirus; Case-Control Studies; Child; Child, Preschool; China; epidemiology; Coronavirus Infections; epidemiology; physiopathology; therapy; Female; Humans; Infant; Infant, Newborn; L-Lactate Dehydrogenase; blood; Male; Middle Aged; Pandemics; Pneumonia, Viral; epidemiology; physiopathology; therapy; Retrospective Studies; Young Adult
- From: Journal of Zhejiang University. Science. B 2020;21(5):369-377
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:A novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in Wuhan, China, has been rapidly spreading around the world. This study investigates the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Zhejiang Province who did or did not have a history of Wuhan exposure.
METHODS:We collected data from medical records of confirmed COVID-19 patients in Zhejiang Province from Jan. 17 to Feb. 7, 2020 and analyzed epidemiological, clinical, and treatment data of those with and without recorded recent exposure in Wuhan.
RESULTS:Patients in the control group were older than those in the exposure group ((48.19±16.13) years vs. (43.47±13.12) years, P<0.001), and more were over 65 years old (15.95% control vs. 5.60% exposure, P<0.001). The rate of clustered onset was also significantly higher in the control group than in the exposure group (31.39% vs. 18.66%, P<0.001). The symptom of a sore throat in patients in the exposure group was significantly higher than that in the control group (17.30% vs. 10.89%, P=0.01); however, headache in the exposure group was significantly lower than that in the control group (6.87% vs. 12.15%, P=0.015). More patients in the exposure group had a significantly lower level of lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) than those in the control group. There was no significant difference in any degree of COVID-19 including mild, severe, and critical between the two groups.
CONCLUSIONS:From the perspective of epidemiological and clinical characteristics, there was no significant difference between COVID-19 patients with and without Wuhan exposure history.