Clinical and Laboratory Features of 6 Cases of Pemphigoid Nodularis.
10.3881/j.issn.1000-503X.12052
- Author:
Xiao-Lei GE
1
;
Si-Zhe LI
1
;
Ya-Gang ZUO
1
;
Wei DU
1
;
Chun-Xia HE
1
Author Information
1. Department of Dermatology,Translational Medicine Center,National Clinical Research Center for Cutaneous and Immunologic Diseases,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- Keywords:
eosinophil;
immunoglobulin E;
pemphigoid nodularis
- MeSH:
Adult;
Aged;
Autoantibodies;
blood;
Enzyme-Linked Immunosorbent Assay;
Eosinophils;
Humans;
Immunoglobulin E;
blood;
Middle Aged;
Pemphigoid, Bullous;
diagnosis;
pathology;
Retrospective Studies
- From:
Acta Academiae Medicinae Sinicae
2020;42(2):197-201
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the clinical manifestations and laboratory characteristics of 6 cases of pemphigoid nodularis (PN). The clinical and laboratory data of 6 patients with PN admitted to the Department of Dermatology,Peking Union Medical College Hospital from January 2016 to August 2019 were retrospectively analyzed. PN mainly occurred in middle-aged and elderly people,with an average age of (58±16) years. Eosinophils were elevated in 4 patients. Immunoglobulin E (IgE) level was (530±672) kU/L in five patients. Direct immunofluorescence showed IgG and/or C3 deposition on basal membrane zone. Indirect immunofluorescence showed positive IgG anti-basement membrane zone,with a titer of 1:40-1:320. Enzyme-linked immunosorbent assay showed the anti-BP180 antibodies were positive [24-85 U/ml,average(43±26) U/ml] in 5 patients. None of the patients had neurological disorders. One patient was lost to follow-up. The disease recurred in 3 of 5 patients during the follow-up,and two patients still received maintenance corticosteroids. PN mainly occurs in middle-aged and elderly individuals. It is featured by elevated eosinophils and total IgE and relatively low anti-BP180 antibody titers. Recurrence is common but PN is less likely to be associated with neurological diseases.
