Research Progress of the Roles of Ubiquitination/Deubiquitination in Androgen Receptor Abnormalities and Prostate Cancer.
10.3881/j.issn.1000-503X.11069
- Author:
Wei-Yu ZHANG
1
;
Jian-Hua ZHOU
2
;
Huan-Rui WANG
1
;
Qing MU
2
;
Qi WANG
1
;
Ke-Xin XU
1
;
Tao XU
1
;
Hao HU
1
Author Information
1. Department of Urology, Peking University People's Hospital,Beijing 100045,China.
2. Department of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People's Hospital,Beijing 100045,China.
- Publication Type:Journal Article
- Keywords:
androgen receptor;
deubiquitination;
prostate cancer;
ubiquitination
- MeSH:
Cell Line, Tumor;
Humans;
Male;
Prostatic Neoplasms;
metabolism;
pathology;
Proteolysis;
Receptors, Androgen;
metabolism;
Ubiquitination
- From:
Acta Academiae Medicinae Sinicae
2020;42(2):251-256
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin is a small molecule protein consisting of 76 amino acids,widely found in eukaryotic cells. The process by which ubiquitin binding to a specific protein is called ubiquitination. Deubiquitination is the reversed process of ubiquitination. Ubiquitination stimulates downstream signal,including complex assembly,protein conformation and activity changes,proteolysis,autophagy,guilt,chromatin remodeling,and DNA repair. More than 80% of eukaryotic protein degradation is mediated by the ubiquitination system,and ubiquitin-dependent proteolysis is an extremely complex process involving many biomolecular processes. By regulating protein homeostasis,ubiquitination can also regulate a variety of biological processes including cell cycle,cell proliferation,and apoptosis,which are closely related to tumorigenesis and progression. Many abnormalities of androgen receptor (AR) including AR gene amplification,mutation,shear mutation,and AR activity enhancement are closely related to prostate cancer progression. In particular,prostate cancer progression is regulated by the ubiquitination/deubiquitination processes. This article summarizes the recent research advances in the roles of ubiquitination/deubiquitination in AR abnormalities and prostate cancer.
