Effect of Infection on Autonomic Nervous Function and Calcitonin Gene-related Peptide in Patients with Functional Dyspepsia.
10.3881/j.issn.1000-503X.11574
- Author:
Mirim KIM
1
;
Nana YANG
1
;
Jiakai SHAO
2
;
Jingwen YANG
1
;
Guangxia SHI
1
;
Chaoqun YAN
2
;
Cunzhi LIU
1
Author Information
1. School of Acupuncture-Moxibustion and Tunia,Beijing University of Chinese Medicine,Beijing 100029,China.
2. Department of Acupuncture and Moxibustion,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China.
- Publication Type:Journal Article
- Keywords:
brain gut peptide;
functional dyspepsia;
heart rate variability;
helicobacter pylori
- MeSH:
Anxiety;
Calcitonin;
Calcitonin Gene-Related Peptide;
Dyspepsia;
Helicobacter Infections;
Helicobacter pylori;
Humans
- From:
Acta Academiae Medicinae Sinicae
2020;42(3):313-318
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of ()infection on autonomic nervous function and calcitonin gene-related peptide in patients with functional dyspepsia(FD). Thirty-one patients with FD matching Rome Ⅳ criteria were included and divided into -positive group and -negative group.All patients were evaluated by Symptom Index of Dyspepsia(SID),Nepean Dyspepsia Index(NDI),and Hospital Anxiety and Depression Scale(HADS).Their heart rate variability(HRV)and calcitonin gene-related peptide(CGRP)level were also measured. There were no significant differences in SID(=-0.858, =0.858),NDI(=-1.464, =0.143),and Hospital Depression Scale score(=0.699, =0.485).However,the Hospital Anxiety Scale score was significantly higher in -positive group than the -negative group(=-2.470, =0.014).The level of CGRP in -positive group[(0.999±0.274)ng/ml]was significantly higher than that in the -negative group[(0.812±0.172)ng/ml;=2.238, =0.033].HRV data showed no significant difference between these two groups at very low frequency(=-1.210, =0.236),low frequency(LF)(=0.419, =0.678),high frequency(HF)(=0.612, =0.546),LF/HF(=-0.882, =0.399),and total power(=-0.963, =0.344). In FD patients,patients with -positive FD patients have higher depression and CGRP levels than those without infection,although their dyspepsia symptoms and HRV show no notable changes.
