Research Advances in Follicular Regulatory T Cells in Ocular Myasthenia Gravis.

Author: Na WU ¹ ; Yuxiang HU ¹ ; Xiaoxuan XU ¹ ; Li YAN ¹ ; Yi CHENG ¹ ; Jie RAO ¹ ; Yajun WU ¹ ; Xiaorong WU ¹
Author Information

1. Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China.
Publication Type:Journal Article
Keywords: follicular help T cells; follicular regulatory T cells; germinal center; ocular myasthenia gravis; pathogenesis
MeSH: Complement System Proteins; Humans; Myasthenia Gravis; Oculomotor Muscles; T-Lymphocytes, Regulatory
From: Acta Academiae Medicinae Sinicae 2020;42(3):383-387
CountryChina
Language:Chinese
Abstract: Myasthenia gravis(MG)is a B cell-mediated,T cell-dependent,complements-involved autoimmune disease.Ocular myasthenia gravis(OMG)is a typical MG,with its symptoms limited to the extraocular muscles.The occurrence and development of a variety of autoimmune diseases including OMG are closely associated with the imbalanced expression of follicular regulatory T cells(Tfr cells).Therefore,Tfr cells may be a new research topic for OMG.