Relationship between Cellular Microenvironment and Idiopathic Pulmonary Fibrosis.
10.3881/j.issn.1000-503X.11249
- Author:
Wei YE
1
;
Mengyang SUN
1
;
Xinhua WANG
1
Author Information
1. First Clinical Medical College,Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China.
- Publication Type:Journal Article
- Keywords:
cellular microenvironment;
cyto-regulatory factor;
extracellular matrix;
idiopathic pulmonary fibrosis;
mesenchymal cells;
unfolded protein response
- MeSH:
Cellular Microenvironment;
Extracellular Matrix;
Humans;
Idiopathic Pulmonary Fibrosis;
Lung
- From:
Acta Academiae Medicinae Sinicae
2020;42(3):410-416
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease characterized by pulmonary interstitial fibrosis and pulmonary dysfunction.Cell microenvironment is mainly composed of cell components,extracellular matrix,extracellular regulators,and liquid substances.Changes in microenvironment components are closely related to IPF.This article elaborates the roles of cell microenvironments including cytokines,mesenchymal cells,extracellular matrix,and unfolded proteins in the pathogenesis of IPF.
