Application Values of Gadolinium-ethoxybenzyl Diethylenetriaminepentaacetic Acid Enhanced Magnetic Resonance Imaging-based Radiomics in the Quantitative Assessment of Liver Reserve Function of Patients with Liver Cirrhosis.
10.3881/j.issn.1000-503X.12620
- Author:
Wei ZHOU
1
;
Hong-Jie HU
2
;
Bo SHEN
1
;
Wei-Qiang SHEN
1
;
Hao CHEN
1
;
Xiao WU
1
;
Qiang YAN
3
;
Pei-Pei PANG
4
Author Information
1. Department of Radiology,Huzhou Central Hospital,Affiliated Central Hospital of Huzhou University,Huzhou,Zhejiang 313000,China.
2. Department of Radiology,Sir Run Run Shaw Hospital of School of Medicine,Zhejiang University,Hangzhou 310016,China.
3. Department of Hepatopancreatobiliary Surgery,Huzhou Central Hospital,Affiliated Central Hospital of Huzhou University,Huzhou,Zhejiang 313000,China.
4. General Electric Pharmaceutical(Shanghai)Co.,Ltd,Hangzhou 310001,China.
- Publication Type:Journal Article
- Keywords:
gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid;
liver cirrhosis;
liver reserve function;
magnetic resonance imaging;
radiomics
- MeSH:
Contrast Media;
Gadolinium DTPA;
Humans;
Liver Cirrhosis;
Magnetic Resonance Imaging
- From:
Acta Academiae Medicinae Sinicae
2020;42(4):459-467
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the correlation between the radiomics signature of hepatobiliary phase imaging of gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid(Gd-EOB-DTPA)enhanced magnetic resonance imaging(MRI)and Child-Pugh of liver cirrhosis,establish nomogram prediction model,and assess the predictive value of quantitative assessment of liver reserve function of patients with liver cirrhosis. One hundred patients with liver cirrhosis who met the inclusion criteria were divided into 52 patients with Child-Pugh grade A and 48 patients with Child-Pugh grade B+C according to Child-Pugh classification criteria,and were randomly divided into training set and test set at a proportion of 7∶3.The AK software was used to extract the imaging features of the Gd-EOB-DTPA-enhanced MRI hepatobiliary images of the patients in the training set,and the least absolute shrinkage and selection operator feature selection algorithm was used to reduce the dimension of the data,select the features,and construct the radiomics tags.According to the radiomics label Rad-score,a line chart(nomogram)prediction model was established to predict the Child-Pugh B+C level of liver reserve function.The model was applied to the training set and test set respectively,and the diagnostic efficiency was quantitatively evaluated by receiver operating characteristic(ROC)curve. After dimension reduction and screening of 396 texture feature parameters extracted by AK software,7 image feature parameters were obtained.According to the above characteristics,the radiomics tag Rad-score was constructed and the nomogram prediction model was created.The differences of Rad-score scores between Child-Pugh A and Child-Pugh B+C groups in training set and test set were statistically analyzed by Wilcoxon rank sum test(=0.000, =0.001).The diagnostic efficacy of nomogram prediction model for predicting Child-Pugh B+C grade of liver reserve function in the ROC curve of training set and test set was 0.88 and 0.86 respectively. The nomogram prediction model created according to the radiomics tag Rad-score of patients with liver cirrhosis with different liver reserve functions can be used as a more accurate and reliable auxiliary detection tool for liver reserve function.It provides a new means for clinicians to evaluate liver reserve function more accurately.
