Impact of the Timing of Traditional Chinese Medicine Therapy on the Therapeutic Effect and Prognosis of Severe Coronavirus Disease 2019.
10.3881/j.issn.1000-503X.12915
- Author:
An ZHANG
1
;
Yan-Ping LI
2
;
Min QIU
3
;
Hua-Bao LIU
4
;
Zhong-Pei CHEN
5
;
Peng WAN
6
;
Yang TAO
6
;
Hui WANG
7
;
Da-Rong WEI
8
;
Qun-Tang LI
9
;
Ya-Lan QIN
1
Author Information
1. Department of Critical Care Medicine,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China.
2. Department of Rheumatology,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China.
3. Department of Oncology,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China.
4. Department of Liver Disease,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China.
5. Department of Endocrinology,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China.
6. Department of Gastroenterology.
7. Department of Respiratory Medicine,Chongqing Beibei District Hospital of Traditional Chinese Medicine,Chongqing 400700,China.
8. Department of Traditional Chinese Medicine,the Three Gorges Central Hospital of Chongqing,Chongqing 404100,China.
9. Treating Potential Diseases Center,Chongqing Traditional Chinese Medicine Hospital,Chongqing 400021,China.
- Publication Type:Journal Article
- Keywords:
coronavirus disease 2019;
prognosis;
therapeutic effect;
therapy combined the traditional Chinese and western medicine;
timing of traditional Chinese medicine therapy
- MeSH:
Betacoronavirus;
Coronavirus Infections;
drug therapy;
Humans;
Medicine, Chinese Traditional;
Pandemics;
Pneumonia, Viral;
drug therapy;
Prognosis;
Retrospective Studies
- From:
Acta Academiae Medicinae Sinicae
2020;42(4):521-530
- CountryChina
- Language:Chinese
-
Abstract:
To explore the optimal therapy time for the treatment of severe coronavirus disease 2019(COVID-19)by traditional Chinese medicine(TCM)and its influence on the therapeutic effect and prognosis. The clinical data,laboratory findings,and outcomes of 64 patients with severe COVID-19 treated with TCM and western medicine in Chongqing from January 20,2020, to March 11,2020 were retrospectively analyzed.Patients were divided into early intervention group[TCM was initiated within 3 days (including day 3) after the first diagnosis of severe type/critical type COVID-19]and late intervention group[TCM was initiated after 7 days (including day 7) after the first diagnosis of severe type /critical type COVID-19].The changes in clinical parameters during the course of disease were compared between the two groups. On day 14,the oxygenation index was 292.5(252.0,351.0)mmHg in the early intervention group,which was significantly higher than that in the late intervention group [246.0(170.0,292.5)mmHg](=0.005).The length of hospital stay [(18.56±1.11)d (24.87±1.64)d,=0.001],duration of ICU stay [(14.12±0.91)d (20.00±1.53)d,=0.000] and time to negativity [(16.77±1.04)d (22.48±1.66)d,=0.001] in the early intervention group were significantly shorter than those in the late intervention group.The intubation rate(7.3%)in the early intervention group was significantly lower than that in the late intervention group(30.4%)(=0.028). Early TCM therapy within three days after a diagnosis of severe COVID-19 can shorten the length of hospital stay,duration of ICU stay,and time to negativity and decrease intubation rate.
