Synergistic Anti-tumor Mechanisms of Low-frequency Ultrasound-targeted Microbubble Destruction:Mechanisms and Application.
10.3881/j.issn.1000-503X.11357
- Author:
Zi-Han NIU
;
Chen-Yang ZHAO
;
Yu-Xin JIANG
- Publication Type:Journal Article
- Keywords:
low frequency ultrasound-targeted microbubble destruction;
nanoparticles;
neoplasm;
sonodynamic therapy;
synergistic therapy
- MeSH:
Contrast Media;
Genetic Therapy;
Humans;
Microbubbles;
Neoplasms;
Ultrasonography
- From:
Acta Academiae Medicinae Sinicae
2020;42(4):540-545
- CountryChina
- Language:Chinese
-
Abstract:
Ultrasound contrast agent microbubbles combined with low frequency ultrasound named as low-frequency ultrasound-targeted microbubble destruction technology has become an effective and non-invasive anti-tumor therapy for deep tumors.It can enhance the efficacies of chemotherapy,gene therapy,immunotherapy,and anti-angiogenic therapy by improving cell membrane permeability and destroying tumor neovasculature.It can be applied to sonodynamic therapy and realize multimodal synergistic therapy on the basis of nanoparticles,which increases the anti-tumor efficiency and offers a promising target therapy for tumors.
