New Research of Nerve Growth Factor on Fracture Healing.
10.3881/j.issn.1000-503X.12062
- Author:
Bing YANG
;
Tian-Yu MA
;
Wei MA
- Publication Type:Journal Article
- Keywords:
fracture healing;
nerve growth factor;
tyrosine kinase receptor A;
vascular endothelial growth factor
- MeSH:
Animals;
Fracture Healing;
Humans;
Nerve Growth Factor
- From:
Acta Academiae Medicinae Sinicae
2020;42(4):546-551
- CountryChina
- Language:Chinese
-
Abstract:
Fracture healing has long been a major concern for orthopedists.Currently,about 10% of fracture patients still have poor fracture healing or bone nonunion.In recent years,research has found that nerve growth factor(NGF)can promote fracture healing.This article reviews the mechanism and research progress of NGF in promoting fracture healing.NGF can promote vascular regeneration and nerve growth at callus and plays an important role in the proliferation and migration of bone cells.New animal experiments and clinical trials have confirmed the role of NGF in promoting fracture healing and further revealed its possible mechanism of action.Further research on NGF can provide new ideas for promoting fracture healing,especially for treating nonunion.
