Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan.
10.1186/s12199-020-00864-7
- Author:
Kiwako YAMAMOTO-HANADA
1
;
Kyongsun PAK
2
;
Mayako SAITO-ABE
3
;
Limin YANG
3
;
Miori SATO
3
;
Hidetoshi MEZAWA
4
;
Hatoko SASAKI
4
;
Minaho NISHIZATO
4
;
Mizuho KONISHI
4
;
Kazue ISHITSUKA
4
;
Kenji MATSUMOTO
4
;
Hirohisa SAITO
4
;
Yukihiro OHYA
3
Author Information
1. Allergy Center, National Center for Child Health and Development, Tokyo, Japan. yamamoto-k@ncchd.go.jp.
2. Division of Biostatistics, Department of Data Management, Center for Clinical Research and Development, National Center for Child Health and Development, Tokyo, Japan.
3. Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
4. Medical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, Tokyo, Japan.
- Collective Name:Japan Environment and Children’s Study (JECS) Group
- Publication Type:Journal Article
- Keywords:
Adjuvant;
Asthma;
Eczema;
Inactivated vaccine;
Wheeze
- MeSH:
Asthma;
epidemiology;
etiology;
Cohort Studies;
Dermatitis, Atopic;
epidemiology;
etiology;
Female;
Food Hypersensitivity;
epidemiology;
etiology;
Humans;
Hypersensitivity;
epidemiology;
etiology;
Infant;
Infant, Newborn;
Japan;
Male;
Vaccines, Inactivated;
adverse effects;
Viral Vaccines;
adverse effects
- From:Environmental Health and Preventive Medicine
2020;25(1):27-27
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant in allergic diseases. We hypothesised that cumulative adjuvant exposure in infancy may influence the development of allergies later in life by changing the balance of type 1/type 2 immunity. We examined the relationship between immunisation with different vaccine types and later allergic disease development.
METHODS:We obtained information regarding vaccinations and allergic diseases through questionnaires that were used in The Japan Environment and Children's Study (JECS), which is a nationwide, multicentre, prospective birth cohort study that included 103,099 pregnant women and their children. We examined potential associations between the initial vaccination before 6 months of age and symptoms related to allergies at 12 months of age.
RESULTS:Our statistical analyses included 56,277 children. Physician-diagnosed asthma was associated with receiving three (aOR 1.395, 95% CI 1.028-1.893) or four to five different inactivated vaccines (aOR 1.544, 95% CI 1.149-2.075), compared with children who received only one inactivated vaccine. Similar results were found for two questionnaire-based symptoms, i.e. wheeze (aOR 1.238, 95% CI 1.094-1.401; three vaccines vs. a single vaccine) and eczema (aOR 1.144, 95% CI 1.007-1.299; four or five vaccines vs. a single vaccine).
CONCLUSIONS:Our results, which should be cautiously interpreted, suggest that the prevalence of asthma, wheeze and eczema among children at 12 months of age might be related to the amount of inactivated vaccine exposure before 6 months of age. Future work should assess if this association is due to cumulative adjuvant exposure. Despite this possible association, we strongly support the global vaccination strategy and recommend that immunisations continue.
TRIAL REGISTRATION:UMIN000030786 .
