Methylmercury toxic mechanism related to protein degradation and chemokine transcription.
10.1186/s12199-020-00868-3
- Author:
Jin-Yong LEE
1
;
Gi-Wook HWANG
2
;
Akira NAGANUMA
3
;
Masahiko SATOH
4
Author Information
1. Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, 464-8650, Japan. leejy@dpc.agu.ac.jp.
2. Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, 981-8558, Japan.
3. Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
4. Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, 464-8650, Japan.
- Publication Type:Journal Article
- Keywords:
Chemokines;
Methylmercury;
Mitochondria;
Pyruvate;
Ubiquitin-proteasome pathway
- MeSH:
Animals;
Chemokines;
drug effects;
metabolism;
Humans;
Methylmercury Compounds;
toxicity;
Mice;
Neurotoxins;
toxicity;
Proteolysis;
drug effects;
Rats;
Saccharomyces cerevisiae;
drug effects
- From:Environmental Health and Preventive Medicine
2020;25(1):30-30
- CountryJapan
- Language:English
-
Abstract:
Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enhance methylmercury toxicity. In addition, methylmercury exposure induces several immune-related chemokines, specifically in the brain, and may cause neurotoxicity. This summary highlights several molecular mechanisms of methylmercury-induced neurotoxicity.
