Risks of Sarcopenia in Patients with Hematological and Oncological Factors who Underwent Hematopoietic Stem Cell Transplantation
- VernacularTitle:血液腫瘍疾患における造血幹細胞移植後の骨格筋量変化とその要因
- Author:
Keisuke HIROTA
1
;
Hiroo MATSUSE
1
;
Ryuki HASHIDA
2
;
Sohei IWANAGA
1
;
Koji NAGAFUJI
2
;
Naoto SHIBA
1
Author Information
- Keywords: sarcopenia; psoas muscle index; muscle mass; hematopoietic stem cell transplantation
- From:The Japanese Journal of Rehabilitation Medicine 2020;57(4):352-363
- CountryJapan
- Language:Japanese
- Abstract: Background and Aims：Sarcopenia is associated with autologous hematopoietic stem cell transplantation (auto-HSCT) -related outcomes in patients with malignant lymphoma (ML). The aims of this study were to investigate changes in skeletal muscle mass after auto-HSCT and risk profiles for sarcopenia after HSCT.Methods：We enrolled 25 patients with refractory ML (age, 57 years [20-69 years]；female/male, 11/14；body mass index, 21.7 kg/m2 [18.9-29.6 kg/m2]). Skeletal muscle mass was evaluated using the psoas muscle index (PMI) measured on computed tomography before and after auto-HSCT. In addition, visceral fat area (VFA) was also measured. Independent factors and profiles associated with a decrease in PMI were evaluated using multivariate and decision-tree analyses, respectively.Results：The PMI was significantly decreased after auto-HSCT (p＝0.0288). A logistic regression analysis revealed that the decreases in PMI and VFA were related. According to the decision-tree analysis, the PMI measured prior to auto-HSCT was selected as the initial branch. Of the patients with a PMI of＜3.74 cm2/m2, 84％ showed a decrease in PMI. Of the patients with a PMI of ≥3.74 cm2/m2, the VFA measured prior to auto-HSCT was the second branch. All the patients with a VFA of ≥115.0 cm2 had decreased PMI.Conclusions：We demonstrated that skeletal muscle mass decreased after auto-HSCT in the patients with ML. The patients with either a PMI of＜3.74 cm2/m2 or a VFA of ≥105.0 cm2 before auto-HSCT were at risk of decreased skeletal muscle mass.
