Anti-tumor Activity and Survival Impact of Whole Adlay Hot Water Extract in Sarcoma Mouse Model

Hirotaka Okuwa-hayashi; Tomihisa Ohta; Satoshi Ohno; Satoru Kyo; Nobutaka Suzuki

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Anti-tumor Activity and Survival Impact of Whole Adlay Hot Water Extract in Sarcoma Mouse Model

VernacularTitle:Anti-tumor Activity and Survival Impact of Whole Adlay Hot Water Extract in Sarcoma Mouse Model
Author: Hirotaka OKUWA-HAYASHI ¹ ; Tomihisa OHTA ² ; Satoshi OHNO ³ ; Satoru KYO ⁴ ; Nobutaka SUZUKI ⁵
Author Information

1. The Faculty of Food Culture, Kurashiki Sakuyo University
2. Kanazawa University, Venture Business Laboratory
3. Clinical Research Support Center, Shimane University, Medical School
4. Department of Obstetrics and Gynecology, Shimane University, Medical School
5. Deaprtment of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
Keywords: whole adlay; hot water extract; Sarcoma; anti-tumor effect; survival; mouse
From:Japanese Journal of Complementary and Alternative Medicine 2020;17(1):37-42
CountryJapan
Language:English
Abstract: Background: Adlay (Coix lacryma-jobi L. var. ma-yuen Stapf) has been used both in traditional Chinese medicine and as a nourishing food based on its unique biological effects and highly nutritional values. In the present study, we investigated the anti-tumor effect of a hot-water adlay extract in sarcoma mice model. Materials and Methods: The hot water extract of whole adlay was orally administered to mice for one week, after which Sarcoma-180 cells (1×106) were subcutaneously implanted into the abdomen. Thereafter, the tumor growth was monitored and mouse survival was examined. Results: Tumor weights measured at 18 days were significantly lower in mice treated with extract (100 and 300 mg/kg/day) than those in control group (p<0.01). Moreover, mice treated with extract (100 mg/kg/day) showed apparently longer survival than control group evaluated until 32 days (p<0.05). Conclusion: These findings indicate that hot water adlay extract appears to have some anti-tumor effects in vivo insarcoma cells.