Toxicity of Dendrobium officinale flowers to pregnantrats and offspring rats before birth
10.19485/j.cnki.issn2096-5087.2020.10.007
- VernacularTitle:铁皮石斛花对孕鼠母体和仔鼠出生前毒性的研究
- Author:
FU Jianyun
1
;
XIA Yong
;
ZHENG Yunyan
;
CAI Delei
;
HE Jiawei
;
SONG Yanhua
Author Information
1. Zhejiang Provincial Center for Disease Control and Prevention
- Publication Type:Journal Article
- Keywords:
Dendrobium officinale flowers rat maternal toxicity toxicity before birth
- From:
Journal of Preventive Medicine
2020;32(10):1000-1003
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To learn the toxicity of Dendrobium officinale flowers to pregnant rats ( P, F1 ) and offspring rats ( F1, F2 ) before birth, so as to provide toxicological evidence for the safety assessment.
Methods :The rats were divided into four groups with 20 female rats and 10 male each. The rats in three dose groups were fed with Dendrobium officinale flowers at the dose of 2.0, 4.0, 6.4g/kgbw. After two generation, the F1a and F2a rats were fed with basal diet; F1b and F2b rats were fed with Dendrobium officinale flowers. The body weights and total weight gains during the gestation, the conception rates, the pregnancy rates, the birth weights and survival rates of offspring rats were examined.
Results:There were no statistically significant differences in the body weights and total weight gains during the gestation, the conception rates, and the pregnancy rates in pregnant rats ( P, F1 ) among the four groups ( P>0.05 ). There were also no statistically significant differences in the survival rates and live birth rates in offspring rats (F1, F2) between the dose groups and the control group ( P>0.05 ).
Conclusions:Dendrobium officinale flowers did not show obviously adverse effects on pregnant rats ( P, F1 ) and offspring rats ( F1, F2 ) before birth.
- Full text:铁皮石斛花对孕鼠母体和仔鼠出生前毒性的研究.pdf
