Research progress on the regulation of tumor metabolism, tumor immunotherapy and new analytical methods
10.16438/j.0513-4870.2020-1025
- VernacularTitle:肿瘤代谢调控与肿瘤免疫治疗以及代谢分析方法研究进展
- Author:
Xiang-yi WANG
1
;
Jin ZHANG
1
;
Yan LI
2
;
Jiu-ming HE
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
tumor metabolism;
tumor immune escape;
immunotherapy;
metabolomics;
mass spectrometry imaging;
metabolic flux
- From:
Acta Pharmaceutica Sinica
2020;55(9):2080-2091
- CountryChina
- Language:Chinese
-
Abstract:
In order to achieve rapid proliferation and adapt to the complex microenvironment, tumor cells have dominant characteristics such as unique metabolic patterns and the ability to escape from immunoregulation. Tumor cells reprogram multiple metabolic pathways to promote immune escape, which impacts tumor diagnosis, treatment and prognosis. Based on the effect of metabolic changes on tumor immune escape and its molecular mechanism, metabolic regulation provides new approaches to enhance immunotherapy. We review recent advances in tumor immuno-escape and immunotherapy based on metabolic regulation. Cutting-edge analytical techniques and methods for tumor metabolism research such as metabolomics, mass spectrometry imaging-based spatially-resolved metabolomics and metabolic flow analysis are also discussed.
