Biosynthesis and transcriptional regulation of tanshinones and salvianolic acids
10.16438/j.0513-4870.2020-0429
- VernacularTitle:丹参酮和丹酚酸类化合物的生物合成及其转录调控机制
- Author:
Zhong-gen ZHAN
1
;
Xing LI
1
Author Information
1. Biophamaceutical Laboratory, Zhejiang Institute of Economics and Trade, Hangzhou 310018, China
- Publication Type:Research Article
- Keywords:
tanshinone;
salvianolic acid;
biosynthesis pathway;
transcription factor
- From:
Acta Pharmaceutica Sinica
2020;55(9):2110-2121
- CountryChina
- Language:Chinese
-
Abstract:
Tanshinones and salvianolic acids are important materials in the treatment of coronary heart disease, myocardial infarction, hypertension, hyperlipidemia, stroke and others illnesses. In recent years, with the development of genomics, transcriptome, metabolomics and bioinformatics, many advances have been made in the biosynthesis and transcriptional regulation of tanshinones and salvianolic acids. This paper summarizes these advances and suggests further study on the downstream synthesis pathways and transcriptional regulatory mechanisms to reveal new molecular mechanism of synthesis, transport, regulation and modification. Additionally, we discuss the design and construction of new biological pathways to increase the expression of biosynthesis genes and the production of secondary components, is a newly developing research field.
