Radioisotope Treatment for Benign Strictures of Non-vascular Luminal Organs.
- Author:
Ji Hoon SHIN
1
Author Information
1. Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. jhshin@amc.seoul.kr
- Publication Type:Review
- Keywords:
radioisotope application;
stents and prostheses;
balloon dilation
- MeSH:
Animals;
Constriction, Pathologic*;
Humans;
Hyperplasia;
Phenobarbital*;
Research Personnel;
Stents
- From:Nuclear Medicine and Molecular Imaging
2006;40(2):106-112
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Tissue hyperplasia is one of the most frequently encountered complications when self-expanding metallic stents are placed in benign non-vascular luminal organ strictures, thus causing restenosis of the lumen. The investigators postulated that ionizing irradiation could be applied to prevent restenosis caused by tissue hyperplasia in non-vascular luminal organs as it reduced coronary or peripheral arterial narrowing successfully. The authors combined beta-irradiation using 188Re-MAG3 solution with balloon dilation for animal and clinical studies because this new treatment approach had the advantages such as low penetration depth of beta-ray, self-centering irradiation, and mechanical effect of balloon dilation over using gamma-irradiation with afterloading devices. In this article, the concept and mechanism of radioisotope balloon dilation, and animal and clinical studies using radioisotope balloon dilation are reviewed.
