Research progress in the mechanism of kidney injury caused by SARS-CoV-2
10.3969/j.issn.1006-2483.2020.04.025
- VernacularTitle:新型冠状病毒感染致肾脏损伤机制进展
- Author:
Linglu LU
1
;
Yunhao LIU
1
;
Ling ZHANG
1
Author Information
1. Department of Environmental Health and Occupational Medicine, School of Public Health, College of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China
- Publication Type:Journal Article
- Keywords:
SARS-CoV-2;
Kidney injury;
Angiotensin converting enzyme 2 (ACE2);
Cytokine storm;
Extracellular matrix metalloproteinase inducer (CD147)
- From:
Journal of Public Health and Preventive Medicine
2020;31(4):101-105
- CountryChina
- Language:Chinese
-
Abstract:
Following the outbreak of Severe Acute Respiratory Syndrome (SARS) in 2003 and the outbreak of Middle East Respiratory Syndrome (MERS) in 2013, a new type of coronavirus (SARS-CoV-2) occurred at the end of 2019, which caused a global pandemic. Many infected people eventually died of multiple organ failure, among which kidney injury was one of the main complications of the virus. Kidney injury is of great significance for the condition judgment and prognosis evaluation of patients with new coronary pneumonia. Renin-Angiotensin-System (RAS), angiotensin converting enzyme 2 (ACE2), cytokine storm, and extracellular matrix metalloproteinase inducer (CD147) are considered to be closely related to the mechanism of kidney injury caused by SARS-CoV-2.
