Iron Deficiency in Heart Failure Patients with Reduced Ejection Fraction and the Correlation with Left Ventricular Ejection Fraction
- Author:
Tan Kok Leng
1
Author Information
- Collective Name:Seng Loong Ng; Soon Eu Chong; W Yus Haniff W Isa; Hady; Jun Jie Tan; Zurkurnai Yusof
- Publication Type:Journal Article
- Keywords: Iron Deficiency; Heart Failure; Ejection Fraction; Anaemia
- From:Malaysian Journal of Medicine and Health Sciences 2020;16(No.1):126-130
- CountryMalaysia
- Language:English
- Abstract: Iron deficiency (ID) has recently been identified as a threat to patients with heart failure with reduced ejection fraction (HFrEF). This study was conducted to determine the occurrence of ID among HFrEF patients in a Malaysian tertiary hospital and its correlation between left ventricular ejection fraction (LVEF). Methods: Stable patients with LVEF less than 45% were included. Demographic data, LVEF (Simpsons) and cardiac functional status were studied, along with full blood count and iron profile. Results: 81 patients with a mean LVEF of 33.6% were recruited. 43.2% of them were NYHA class II patients, followed by 38.3% class III, 13.6% class I and 4.9% class IV patients. About 2/5 of the study population were anaemic, and of those, 48.5% were iron deficient. Majority of these anaemic patients (87.5%) had an absolute iron deficiency. Pearson’s statistical analysis showed positive correlation between ejection fraction and serum ferritin (r=0.624, p< 0.001), serum iron (r= 0.302, p<0.05), transferrin saturation (r= 0.346, p<0.001) and haemoglobin (r=0.528, p <0.001). Among the HFrEF patients, mean LVEF of those without anaemia and without ID were the highest (35.75+4.35%), followed by anaemic patients without ID (31.71+4.47%) and anaemic patients with ID (28.94+2.57%). There was also a trend showing that anaemic patients with ID were associated with higher NYHA functional class. Conclusions: ID is correlated with HFrEF in this single tertiary centre of a developing country. Further studies are needed to explore this potential nutritional therapeutic target that may be used in the updates of existing advisory.
- Full text:11.2020my0582.pdf
