The Influence of Age and Prostate Volume on the Cancer Detection Rate in Korean Men with PSA Levels of 4.0 to 10.0ng/ml: a Multicenter, Retrospective Study.
10.4111/kju.2006.47.4.353
- Author:
Do Hwan SEONG
1
;
Jin Seon CHO
;
Sung Joon HONG
;
Byung Ha CHUNG
;
Young Deuk CHOI
;
Se Joong KIM
;
Dong Hyeon LEE
;
In Rae CHO
;
Young Sik KIM
;
Chun Il KIM
;
Sun Il KIM
;
Jae Man SONG
;
Sang Hyeon CHEON
;
Hong Sup KIM
Author Information
1. Department of Urology, College of Medicine, Inha University, Incheon, Korea.
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Prostate-specific antigen;
Prostate cancer
- MeSH:
Biopsy;
Humans;
Male;
Middle Aged;
Prostate*;
Prostate-Specific Antigen;
Prostatic Neoplasms;
Retrospective Studies*;
Ultrasonography
- From:Korean Journal of Urology
2006;47(4):353-357
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We retrospectively investigated how patients age and prostate volume influence on the cancer detection rate in Korean men with prostate-specific antigen (PSA) levels of 4.0 to 10.0ng/ml. MATERIALS AND METHODS: 791 Korean men who underwent transrectal ultrasound guided prostate biopsies (TRBx) at 12 medical centers were analyzed retrospectively during the previous 10 years. TRBx were performed in cases with PSA levels of 4.0 to 10.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD. RESULTS: Among the 791 patients who underwent TRBx, prostate cancer was detected in 123 patients (15.5%). The mean age (cancer group vs non-cancer group=69.1 vs 63.8 year-old), prostate volume (38.0 vs 42.5ml, respectively) and PSAD (0.21 vs 0.18ng/ml/ml, respectively) were found in statistically significant between the two groups. The cancer detection rate (20.1%) in the small prostate (less than 40ml) was significantly higher than that (10.3%) of the large prostate. The cancer detection rate was significantly increased with age: from 14.4% for the 50 to 59 year-old patients to 31.6% for the 80 or more year-old patients. CONCLUSIONS: The cancer detection rate in Korean men with a gray zone PSA level is lower than that of Caucasians. However, regarding the detection of prostate cancer in Korean men, the older age group and the patients with less than 40ml of prostate volume among the patients with gray zone PSA levels are considered as the important factors to decide whether biopsy of prostate is needed.
