The protective effect of Rhizoma Coptidis extracts against the sepsis associated with acute kidney injury based on metabolic analysis
10.12206/j.issn.1006-0111.202003127
- VernacularTitle:黄连提取物减轻脓毒症相关急性肾损伤的代谢组学研究
- Author:
Yuenan ZHENG
1
;
Guojian SHAO
1
;
Yifan ZHANG
1
;
Lingjiu SHAO
1
;
Qi ZHOU
2
;
Yachen SI
2
Author Information
1. Department of Nephrology, Wenzhou Central Hospital, Wenzhou 325000，China.
2. Graduate School, Naval Medical University, Shanghai 200433，China.
- Keywords:
sepsis;
acute kidney injury;
Rhizoma Coptidis;
metabonomics
- From:
Journal of Pharmaceutical Practice
2020;38(5):435-440
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential mechanism of Rhizoma Coptidis extracts (RCE) against sepsis associated with acute kidney injury. Methods C57BL/6 mice were divided into sham group, model group and RCE treatment group. The levels of Scr and BUN were measured by test kits. Gas chromatography-mass spectrometry was used to analyze metabolic changes in kidneys. Results The levels of Scr and BUN were increased in the model group than sham, which were reversed by RCE. 16 metabolites related to the progress of sepsis associated with acute kidney injury were detected, which were involved in amino acid metabolism and carbohydrate metabolism. Among these metabolites, the level of 8 metabolites can be reversed with RCE treatment. Conclusion RCE might exert therapeutic effects in sepsis associated with acute kidney injury by altering multiple metabolic pathways.
