Effects of compound Ziyin granule on sex hormones and oxidative stress levels of ovariectomized rats
10.12206/j.issn.1006-0111.201912023
- VernacularTitle:复方滋阴颗粒对去卵巢大鼠性激素和氧化应激水平的影响
- Author:
Jun QIAN
1
;
Fan XIE
1
;
Kezhao WEI
2
;
Jianping GAO
2
;
Wenyan LI
1
Author Information
1. Department of Pharmacy, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, China.
2. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
- Keywords:
compound Ziyin granule;
perimenopause;
sex hormones;
antioxidation capacity;
rats
- From:
Journal of Pharmaceutical Practice
2020;38(5):431-434
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of compound Ziyin granule (CZG) on sex hormones and oxidative stress levels of ovariectomized rats. Methods The experiment was divided into model group, Liuwei Dihuang pill group, estradiol valerate group, Zishen Yangyin Decoction group, CZG (low, medium, high dose) group, ormal group and sham operation group. After administration for 8 weeks, serum estradiol (E2), follicle stimulation hormone (FSH), luteotropic hormone (LH), total-superoxide dismutase (T-SOD), malonaldehyde (MDA) and glutathione peroxidase (GSH-Px) were measured. Results Compared with the model group, E2 was significantly raised at medium and high doses of CZG, LH was decreased at medium dose, and FSH was reduced at low, medium and high dose; medium and high dose of CZG were capable of remarkably increasing T-SOD, GSH-Px and decreasing MDA, and low dose raised T-SOD and reduced MDA (P<0.05 or P<0.01). Compared with estradiol valerate group, low dose of CZG significantly increased T-SOD (P<0.05). Compared with decoction group, GSH-Px was remarkably raised at medium and high dose (P<0.05). Conclusion The CZG could reverse the abnormal function of sex hormone secretion in the pituitary-ovary axis of the ovariectomy perimenopausal model rat and improve its antioxidant capacity.
