Research progress on risk factors of de novo malignancy after liver transplantation
10.3969/j.issn.1674-7445.2020.05.019
- VernacularTitle:肝移植术后新发恶性肿瘤危险因素的研究进展
- Author:
Lingzhan MENG
1
;
Zhenwen LIU
;
Zhenyu ZHU
Author Information
1. Department of Hepatobiliary Surgery, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
- Publication Type:Research Article
- Keywords:
Liver transplantation;
De novo malignancy;
Immunosuppression;
Mammalian target of rapamycin (mTOR) inhibitor;
Hepatocellular carcinoma;
Virus infection;
Precancerous lesion;
Smoking-related malignancy
- From:
Organ Transplantation
2020;11(5):646-
- CountryChina
- Language:Chinese
-
Abstract:
De novo malignancy after liver transplantation is an important factor that affecting the long-term survival of recipient. The main risk factors for de novo malignancy include immunosuppression and many factors of recipients, such as age, gender, race, primary disease, preoperative tumor history and precancerous lesion, carcinogenic virus infection, smoking and drinking, etc. Currently, there is no standardized monitoring scheme after liver transplantation, but planned monitoring is required for high-risk recipients, thus to achieve early diagnosis and improve the survival rate. This article summarized the incidence, prognosis and related risk factors of de novo malignancy after liver transplantation, which provided reference for improving long-term survival rate of recipients after liver transplantation.
