Research progress on pharmacokinetics of mycophenolic acid drugs in organ transplant recipients
10.3969/j.issn.1674-7445.2020.05.018
- VernacularTitle:霉酚酸类药物在器官移植受者中的药代动力学研究进展
- Author:
Yirui CAO
1
;
Yichen JIA
Author Information
1. Department of Urology, Zhongshan Hospital Affiliated to Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai 200320, China
- Publication Type:Research Article
- Keywords:
Mycophenolic acid;
Organ transplantation;
Pharmacokinetics;
Immunosuppressant;
Calcineurin inhibitor;
Mycophenolate mofetil
- From:
Organ Transplantation
2020;11(5):635-
- CountryChina
- Language:Chinese
-
Abstract:
Mycophenolic acid (MPA) drugs are common immunosuppressant for organ transplant recipients, which possesses high immunosuppressive effect. However, insufficient or excessive dosage of MPA is not conducive to clinical prognosis of the recipients. Hence, it is necessary to accurately control the dosage of MPA. The metabolism of MPA significantly differs among individuals. The metabolic pattern and monitoring method of these drugs are of important significance in clinic. In this article, the research progresses on the metabolism of MPA drugs in organ transplant recipients in recent five years were reviewed, the main results and direction of drug metabolism and monitoring methods were summarized, and the researches on the metabolism of MPA drugs in organ transplantation were briefly reviewed and prospected.
