Research progress on dendritic cell in immune tolerance of organ transplantation
10.3969/j.issn.1674-7445.2020.05.017
- VernacularTitle:树突状细胞在器官移植免疫耐受中的研究进展
- Author:
Junming XU
1
;
Lin ZHOU
;
Qiang HE
Author Information
1. Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
- Publication Type:Research Article
- Keywords:
Dendritic cell;
Organ transplantation;
Immune tolerance;
Immune response;
Immune regulation;
Immunosuppressant;
Cytokine;
Genetic engineering
- From:
Organ Transplantation
2020;11(5):629-
- CountryChina
- Language:Chinese
-
Abstract:
Dendritic cell (DC) is professional antigen presenting cell with specific functions. DC can specifically phagocytize antigen, and process and deliver to effector T cell, which play an important role in immune tolerance and immune response. Tolerance DC (tol-DC) is a group of DC with negative immune regulatory function, which can induce immune tolerance of organ transplantation through central and peripheral mechanism. In this article, the phenotype and functional characteristics of DC, mechanism of immune tolerance induced by DC, and the application of tol-DC in organ transplantation of DC were summarized, aiming to provide basic theoretical support for clinical translational medicine research.
