Supercooling organ preservation technology and its application
10.3969/j.issn.1674-7445.2020.05.002
- VernacularTitle:超冷器官保存技术及应用
- Author:
Qiang LU
1
;
Wei ZHANG
;
Lifei YANG
;
Yi LYU
Author Information
1. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China
- Publication Type:Research Article
- Keywords:
Organ transplantation;
Organ preservation;
Supercooling organ preservation;
Static cold storage;
Cell metabolism;
Normothermic machine perfusion;
Subnormothermic machine perfusion;
Hypothermic machine perfusion
- From:
Organ Transplantation
2020;11(5):543-
- CountryChina
- Language:Chinese
-
Abstract:
The main purpose of organ preservation in organ transplantation is to maintain tissue and cell activity of donor organs so as to gain time for allocation and transportation of the organ, preparation of the recipient and organization of staff and facilities. The main principles of organ preservation can be divided into normothermic mechanical perfusion and cryopreservation. Cryopreservation is the favourite organ preservation method in clinical practice currently. However, the metabolic activity still exists in donor organs preserved with current cryopreservation technique, which makes the long-term preservation of organs extremely difficult. The supercooling organ preservation is a new type of cryopreservation technology, which greatly prolongs the preservation time of organs. It is expected to become an important organ preservation technique in the future, and it will provide technical support for the establishment of "organ bank".
