Anti-Hypolipidemic and Anti- Oxidative Effects of Hydroalcoholic Extract of Origanum majorana on the Hepatosteatosis Induced with High-Fat Diet in Rats
- Author:
Abdolmomen Ghaeni Pasavei
;
Reza Mohebbati
;
Nadia Boroumand
;
Ahmad Ghorban
;
Azar Hosseini
;
Shirin Taraz Jamshidi4
;
Mohammad Soukhtanloo
- Publication Type:Journal Article
- Keywords:
non-alcoholic fatty liver disease;
oxidative stress;
Origanum majorana;
high-fat diet
- From:Malaysian Journal of Medical Sciences
2020;27(1):57-69
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: The aim of the current study is to evaluate the antihyperlipidemic and antioxidative effects of hydro-alcoholic extract of marjoram (HAEM) in rats fed with a high-fat diet
(HFD).
Methods: In the experimental study, the rats were randomly divided into four groups of
five rats in each and fed with high-fat diet for 12 weeks as follows: One group (normal diet group)
was fed with a standard diet, one group was fed with HFD, and two groups were fed with HFD and
orally fed with 150 and 450 mg/kg/day HAEM. The serum samples and liver tissues were used for
measuring the biochemical and oxidative parameters and histopathological studies. HFD induced
hepatosteatosis in rats as evidenced by the altered liver enzymes activity, serum lipid profile and
oxidative status.
Results: Serum lipid profile (triglyceride, cholesterol and low-density lipoprotein) in
rats fed with HFD + HAEM (150 and 450 mg/kg/day) was significantly decreased. Furthermore,
the evaluation of oxidative stress showed a reduction of the malondialdehyde (MDA) level and
an increase in ferric-reducing anti-oxidant power. Meanwhile, liver enzyme activities declined in
response to HAEM.
Conclusion: Using the HAEM could be a future therapeutic agent in treating
hepatosteatosis and reducing oxidative damages of HFD in the liver.
- Full text:3.2020my0839.pdf
